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Although there are several NP databases - Dictionary of Natural Products 2, AntiBase 3 and MarinLit 4 - that assist in dereplication (identification of known compounds), these resources are not freely available and do not process mass spectrometry data. The potentially useful information in MS/MS datasets can thus remain buried in papers, laboratory notebooks, and private databases, hindering retrieval, mining, and sharing of data and knowledge. #Trents box set of tutorials vol 4 download torrent software#Further, comprehensive software and proper computational infrastructure are not readily available and only low-throughput sharing of either raw or annotated spectra is feasible, even among members of the same lab. #Trents box set of tutorials vol 4 download torrent manual#These datasets are too large for manual analysis. However a single mass spectrometry experiment can collect thousands of MS/MS spectra in minutes 1 and individual projects can acquire millions of spectra. Natural products (NPs) from marine and terrestrial environments, including their inhabiting microorganisms, plants, animals, and humans, are routinely analyzed using mass spectrometry. We also introduce the concept of ‘living data’ through continuous reanalysis of deposited data. Data-driven social-networking should facilitate identification of spectra and foster collaborations. In GNPS crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations. We present Global Natural Products Social molecular networking (GNPS, ), an open-access knowledge base for community wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. Although mass spectrometry techniques are well-suited to high-throughput characterization of natural products, there is a pressing need for an infrastructure to enable sharing and curation of data. The potential of the diverse chemistries present in natural products (NP) for biotechnology and medicine remains untapped because NP databases are not searchable with raw data and the NP community has no way to share data other than in published papers. Rodríguez, 32 Anne Lamsa, 44 Chen Zhang, 45 Kathleen Dorrestein, 3 Brendan M Duggan, 3 Jehad Almaliti, 3 Pierre-Marie Allard, 46 Prasad Phapale, 47 Louis-Felix Nothias, 48 Theodore Alexandrov, 47 Marc Litaudon, 48 Jean-Luc Wolfender, 46 Jennifer E Kyle, 49 Thomas O Metz, 49 Tyler Peryea, 50 Dac-Trung Nguyen, 50 Danielle VanLeer, 50 Paul Shinn, 50 Ajit Jadhav, 50 Rolf Müller, 41 Katrina M Waters, 49 Wenyuan Shi, 20 Xueting Liu, 51 Lixin Zhang, 51 Rob Knight, 52 Paul R Jensen, 6 Bernhard O Palsson, 37 Kit Pogliano, 44 Roger G Linington, 36 Marcelino Gutiérrez, 12 Norberto P Lopes, 32 William H Gerwick, 3, 6 Bradley S Moore, 3, 6, 42 Pieter C Dorrestein, 3, 6, 31 and Nuno Bandeira 2, 3, 31 ![]() Helfrich, 22 Eve A Granatosky, 35 Evgenia Glukhov, 6 Florian Ryffel, 22 Hailey Houson, 7 Hosein Mohimani, 2 Jenan J Kharbush, 6 Yi Zeng, 4 Julia A Vorholt, 22 Kenji L Kurita, 36 Pep Charusanti, 37 Kerry L McPhail, 38 Kristian Fog Nielsen, 18 Lisa Vuong, 7 Maryam Elfeki, 23 Matthew F Traxler, 39 Niclas Engene, 40 Nobuhiro Koyama, 3 Oliver B Vining, 38 Ralph Baric, 28 Ricardo R Silva, 32 Samantha J Mascuch, 6 Sophie Tomasi, 15 Stefan Jenkins, 13 Venkat Macherla, 7 Thomas Hoffman, 41 Vinayak Agarwal, 42 Philip G Williams, 43 Jingqui Dai, 43 Ram Neupane, 43 Joshua Gurr, 43 Andrés M. Johnson, 29 Ashley M Sidebottom, 29 Brian E Sedio, 30, 12 Andreas Klitgaard, 18 Charles B Larson, 6, 31 Cristopher A Boya P., 12 Daniel Torres-Mendoza, 12 David J Gonzalez, 31, 3 Denise B Silva, 32, 33 Lucas M Marques, 32 Daniel P Demarque, 32 Egle Pociute, 7 Ellis C O'Neill, 6 Enora Briand, 6, 34 Eric J. ![]() ![]() Mingxun Wang, # 1, 2 Jeremy J Carver, # 1, 2 Vanessa V Phelan, # 3 Laura M Sanchez, # 3 Neha Garg, # 3 Yao Peng, # 4 Don Duy Nguyen, 4 Jeramie Watrous, 3 Clifford A Kapono, 4 Tal Luzzatto-Knaan, 3 Carla Porto, 3 Amina Bouslimani, 3 Alexey V Melnik, 3 Michael J Meehan, 3 Wei-Ting Liu, 5 Max Crüsemann, 6 Paul D Boudreau, 6 Eduardo Esquenazi, 7 Mario Sandoval-Calderón, 8 Roland D Kersten, 9 Laura A Pace, 3 Robert A Quinn, 10 Katherine R Duncan, 11, 6 Cheng-Chih Hsu, 4 Dimitrios J Floros, 4 Ronnie G Gavilan, 12 Karin Kleigrewe, 6 Trent Northen, 13 Rachel J Dutton, 14 Delphine Parrot, 15 Erin E Carlson, 16 Bertrand Aigle, 17 Charlotte F Michelsen, 18 Lars Jelsbak, 18 Christian Sohlenkamp, 8 Pavel Pevzner, 2, 1 Anna Edlund, 19, 20 Jeffrey McLean, 21, 20 Jörn Piel, 22 Brian T Murphy, 23 Lena Gerwick, 6 Chih-Chuang Liaw, 24 Yu-Liang Yang, 25 Hans-Ulrich Humpf, 26 Maria Maansson, 18 Robert A Keyzers, 27 Amy C Sims, 28 Andrew R. ![]()
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